Human apolipoprotein C-I expression in mice impairs learning and memory functions.

@article{Abildayeva2008HumanAC,
  title={Human apolipoprotein C-I expression in mice impairs learning and memory functions.},
  author={Karlygash Abildayeva and Jimmy F P Berb{\'e}e and Arjan Blokland and Paula J. Jansen and Frans van Hoek and Onno C Meijer and Dieter L{\"u}tjohann and Thierry Gautier and Thierry Pillot and Jan de Vente and Louis M. Havekes and Frans C. S. Ramaekers and Folkert Kuipers and Patrick C. N. Rensen and Monique T. Mulder},
  journal={Journal of lipid research},
  year={2008},
  volume={49 4},
  pages={
          856-69
        }
}
The H2 allele of APOC1, giving rise to increased gene expression of apolipoprotein C-I (apoC-I), is in genetic disequilibrium with the APOE4 allele and may provide a major risk factor for Alzheimer's disease (AD). We found that apoC-I protein is present in astrocytes and endothelial cells within hippocampal regions in both human control and AD brains. Interestingly, apoC-I colocalized with beta-amyloid (Abeta) in plaques in AD brains, and in vitro experiments revealed that aggregation of Abeta… CONTINUE READING

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