Human apolipoprotein A-II is a pro-atherogenic molecule when it is expressed in transgenic mice at a level similar to that in humans: evidence of a potentially relevant species-specific interaction with diet.

@article{EscolGil1998HumanAA,
  title={Human apolipoprotein A-II is a pro-atherogenic molecule when it is expressed in transgenic mice at a level similar to that in humans: evidence of a potentially relevant species-specific interaction with diet.},
  author={Joan Carles Escol{\`a}-Gil and A Marzal-Casacuberta and J Julve-Gil and Brian Y. Ishida and Jordi Ord{\'o}{\~n}ez-Llanos and Lawrence K Chan and Francesc Gonz{\'a}lez-Sastre and Francisco Blanco-Vaca},
  journal={Journal of lipid research},
  year={1998},
  volume={39 2},
  pages={457-62}
}
We report on the effect of human apolipoprotein (apo) A-II transgene expression on atherosclerosis susceptibility in two transgenic lines (25.3 and 11.1) whose plasma human apoA-II concentrations (approximately 23 and 96 mg/dl, respectively) span the normal range in humans. After 9 months of an atherogenic diet, 25.3 and 11.1 transgenic mice developed aortic atherosclerotic lesions that were approximately 1.7- and 7-fold, respectively, more extensive than those of non-transgenic control mice… CONTINUE READING

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