Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy.

@article{Linthout2008HumanAA,
  title={Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy.},
  author={Sophie Van Linthout and Frank Spillmann and A. R. Riad and Christiane Trimpert and Joke Lievens and Marco M. Meloni and Felicitas Escher and Elena Filenberg and Okan Demir and Jun Li and Mehdi Shakibaei and Ingolf Schimke and Alexander Staudt and Stephan Burkhart Felix and Heinz-Peter Schultheiss and Bart De Geest and Carsten Tsch{\"o}pe},
  journal={Circulation},
  year={2008},
  volume={117 12},
  pages={1563-73}
}
BACKGROUND The hallmarks of diabetic cardiomyopathy are cardiac oxidative stress, intramyocardial inflammation, cardiac fibrosis, and cardiac apoptosis. Given the antioxidative, antiinflammatory, and antiapoptotic potential of high-density lipoprotein (HDL), we evaluated the hypothesis that increased HDL via gene transfer (GT) with human apolipoprotein (apo) A-I, the principal apolipoprotein of HDL, may reduce the development of diabetic cardiomyopathy. METHODS AND RESULTS Intravenous GT with… CONTINUE READING
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