Human aortic smooth muscle cells are insulin resistant at the receptor level but sensitive to IGF1 and IGF2.

@article{Chisalita2009HumanAS,
  title={Human aortic smooth muscle cells are insulin resistant at the receptor level but sensitive to IGF1 and IGF2.},
  author={Simona I Chisalita and Git S Johansson and E Liefvendahl and Karolina B{\"a}ck and Hans J Arnqvist},
  journal={Journal of molecular endocrinology},
  year={2009},
  volume={43 6},
  pages={231-9}
}
Whether insulin, at physiological concentrations, has direct effects on vascular smooth muscle cells (VSMCs) remains controversial. Our aim was to characterize the mechanism for insulin resistance in VSMCs. For comparison, the effects of IGF1 and IGF2 were also studied. Cultured human aortic smooth muscle cells (HASMC) were used. Receptor mRNA was analyzed by quantitative reverse transcription PCR and receptor protein by ELISA and western blot. Biological effects were studied by thymidine… CONTINUE READING

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