Human antibody–Fc receptor interactions illuminated by crystal structures

@article{Woof2004HumanAR,
  title={Human antibody–Fc receptor interactions illuminated by crystal structures},
  author={J. M. Woof and D. Burton},
  journal={Nature Reviews Immunology},
  year={2004},
  volume={4},
  pages={89-99}
}
  • J. M. Woof, D. Burton
  • Published 2004
  • Biology, Medicine
  • Nature Reviews Immunology
  • Immunoglobulins couple the recognition of invading pathogens with the triggering of potent effector mechanisms for pathogen elimination. Different immunoglobulin classes trigger different effector mechanisms through interaction of immunoglobulin Fc regions with specific Fc receptors (FcRs) on immune cells. Here, we review the structural information that is emerging on three human immunoglobulin classes and their FcRs. New insights are provided, including an understanding of the antibody… CONTINUE READING
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    References

    SHOWING 1-10 OF 123 REFERENCES
    Crystal structure of the human leukocyte Fc receptor, FcγRIIa.
    • 153
    Molecular basis for immune complex recognition: a comparison of Fc-receptor structures.
    • 126
    Crystal structure of the extracellular domain of a human Fc gamma RIII.
    • 81
    Interaction of Human IgE with Fc Epsilon RI Alpha Exposes Hidden Epitopes on IgE
    • 6