Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria.

@article{Polley2004HumanAT,
  title={Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria.},
  author={Spencer D. Polley and Tabitha Wanja Mwangi and Clemens H. M. Kocken and Alan W. Thomas and Sheetij Dutta and David E. Lanar and Edmond Joseph Remarque and Amanda Ross and Thomas N Williams and Gabrielle Mwambingu and Brett Lowe and David J Conway and Kevin Marsh},
  journal={Vaccine},
  year={2004},
  volume={23 5},
  pages={718-28}
}
Serum antibodies from 1071 people in two Kenyan villages were assayed using eight different recombinant Apical Membrane Antigen 1 (AMA1) protein constructs to investigate their role in naturally acquired immunity. In both communities, antibodies against the full-length ectodomain (both FVO and 3D7 allele constructs) prior to a malaria transmission season were significantly associated with protection from malaria in the following 6 months, even after adjusting for age and antibody reactivity to… CONTINUE READING

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