Human anti-nucleolin recombinant immunoagent for cancer therapy.

@article{Palmieri2015HumanAR,
  title={Human anti-nucleolin recombinant immunoagent for cancer therapy.},
  author={Dario Palmieri and Timothy Richmond and Claudia Piovan and Tyler Sheetz and Nicola Zanesi and Fulvia Troise and Cindy James and Dorothee Wernicke and Fata Nyei and T. J. Gordon and Jessica Consiglio and Francesco Salvatore and Vincenzo Coppola and Flavia Pichiorri and Claudia De Lorenzo and Carlo M. Croce},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 30},
  pages={9418-23}
}
Nucleolin (NCL) is a nucleocytoplasmic protein involved in many biological processes, such as ribosomal assembly, rRNA processing, and mRNA stabilization. NCL also regulates the biogenesis of specific microRNAs (miRNAs) involved in tumor development and aggressiveness. Interestingly, NCL is expressed on the surface of actively proliferating cancer cells… CONTINUE READING