Human anti-mitochondria autoantibodies appearing in iproniazid-induced immunoallergic hepatitis recognize human liver monoamine oxidase B.

@article{Pons1996HumanAA,
  title={Human anti-mitochondria autoantibodies appearing in iproniazid-induced immunoallergic hepatitis recognize human liver monoamine oxidase B.},
  author={Carmen Santos Pons and Patrick M Dansette and J Gregeois and J{\"o}rg Homberg and Ellen E. Billett and Daniel Mansuy},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={218 1},
  pages={118-24}
}
Anti-mitochondria (anti-M6) autoantibodies have been found in the serum of patients with immunoallergic iproniazid (Marsilid)-induced hepatitis, but to date the identity of the protein antigen has not been determined. Here we show, using immunoprecipitation of pargyline-labelled proteins, that among the mitochondrial proteins, liver MAO-B is specifically recognized by the sera containing anti-M6 antibodies. Moreover the enzymatic activity of MAO-B towards phenylethylamine and tyramine is also… CONTINUE READING