Human anti-FcepsilonRIalpha autoantibodies isolated from healthy donors cross-react with tetanus toxoid.

@article{Horn1999HumanAA,
  title={Human anti-FcepsilonRIalpha autoantibodies isolated from healthy donors cross-react with tetanus toxoid.},
  author={Michael Peter Horn and Thomas Gerster and B Ochensberger and T Derer and Franz Kricek and M. Jouvin and J P Kin{\'e}t and Thomas Tschernig and Monique Vogel and Beda M. Stadler and Sylvia M. Miescher},
  journal={European journal of immunology},
  year={1999},
  volume={29 4},
  pages={1139-48}
}
Natural antibodies (Ab) reacting with self antigens have been shown to be present in all individuals. These autoantibodies (auto-Ab) can be either pathogenic or non-pathogenic. Auto-Ab reacting with the alpha-subunit of the high-affinity receptor for IgE (FcepsilonRIalpha) have been implicated in the pathogenesis of a subset of patients with chronic idiopathic urticaria (CIU). Intravenous immunoglobulin (IVIg) preparations have been used with variable clinical benefit in the treatment of these… CONTINUE READING

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