Human aniridia limbal epithelial cells lack expression of keratins K3 and K12.

@article{Latta2018HumanAL,
  title={Human aniridia limbal epithelial cells lack expression of keratins K3 and K12.},
  author={Lorenz Latta and Arne Viestenz and Tanja Stachon and Sarah Colanesi and Nora Szentm{\'a}ry and Berthold Seitz and Barbara K{\"a}smann-Kellner},
  journal={Experimental eye research},
  year={2018},
  volume={167},
  pages={
          100-109
        }
}
Aniridia is a rare disease of the eye that affects the iris, lens and the cornea. In about 90% of the cases, patients showed a loss of PAX6 function. Patients with aniridia often develop aniridia-related keratopathy (ARK), due to limbal stem cell insufficiency. The aim of this study was to determine the differentiation status of limbal epithelial cells (LECs) in patients with ARK. Epithelial cells were isolated from the limbus region of two patients with aniridia and cultured in KSFM medium… CONTINUE READING