Human androgen‐induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties

@article{Tanaka1995HumanAG,
  title={Human androgen‐induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties},
  author={Akira Tanaka and Kaoru Miyamoto and Hisayuki Matsuo and K. Matsumoto and Hiroki Yoshida},
  journal={FEBS Letters},
  year={1995},
  volume={363}
}
Androgen inducibility of Fgf8 in Shionogi carcinoma 115 cells correlates with an adjacent t(5;19) translocation
TLDR
The results suggest that androgen inducibility is not an inherent property of the Fgf8 gene, which has implications regarding this gene's proposed role in the etiology of hormone‐responsive cancers.
High frequency of fibroblast growth factor (FGF) 8 expression in clinical prostate cancers and breast tissues, immunohistochemically demonstrated by a newly established neutralizing monoclonal antibody against FGF 8.
TLDR
It is demonstrated that FGF 8 was frequently expressed in human prostate cancers, appearing in 40 of 43 cases (93%), whereas both prostatic hyperplasia specimens and normal prostate tissues included in biopsy specimens were negative for FGF 7 expression.
Activation of fibroblast growth factor 8 gene expression in human embryonal carcinoma cells
Advances in Brief High Frequency of Fibroblast Growth Factor ( FGF ) 8 Expression in Clinical Prostate Cancers and Breast Tissues , Immunohistochemically Demonstrated by a Newly Established Neutralizing Monoclonal Antibody against FGF 81
TLDR
Immunohistochemical analyses by use of the established anti-FGF 8 antibody demonstrated that FGF 8 was frequently expressed in human prostate cancers, appearing in 40 of 43 cases, whereas both prostatic hyperplasia specimens and normal prostate tissues included in biopsy specimens were negative for FGF 7 expression.
Enhanced invasion and tumor growth of fibroblast growth factor 8b-overexpressing MCF-7 human breast cancer cells.
TLDR
FGF-8b signaling may be an important factor in the regulation of tumorigenesis and progression of human breast cancer, both in vitro and in vivo.
FGF8 over-expression in prostate cancer is associated with decreased patient survival and persists in androgen independent disease
TLDR
In vitro studies demonstrated that in the presence of neutralizing antibody to F GF8b there was significant inhibition of prostate cancer cell growth, confirming the biological significance of FGF8 in prostate carcinogenesis.
Role of fibroblast growth factor 8 in growth and progression of hormonal cancer.
Fibroblast growth factor 8 expression in breast carcinoma: associations with androgen receptor and prostate-specific antigen expressions
TLDR
FGF8 expression was significantly associated with androgen-receptor status and the expression of prostate-specific antigen (PSA) in human breast carcinomas, which support the reported in vitro data demonstrating the regulation of FGF8 by androgens, and suggest that PSA may be a useful marker for patients with F GF8-expressing breast carcinoma.
The effect of fibroblast growth factor 8, isoform b, on the biology of prostate carcinoma cells and their interaction with stromal cells.
TLDR
The growth rate and biological behavior of prostatic cancer cells can be altered to a more aggressive phenotype by up-regulation of FGF8b expression, and changes in phenotype also influence the interaction of the affected cells with stromal cells.
Increased expression of fibroblast growth factor 8 in human breast cancer
TLDR
This is the first member of the FGF family to have increased expression in breast cancer and a potential autocrine role in its progression, and an autocrine activation loop is possible.
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The results suggest that alterations in HBGF gene expression in both prostate epithelial and mesenchymal cells and in properties of the receptor in specifically epithelial cells may contribute to differential growth rates and malignancy of different prostatic tumors.
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The embryonic expression pattern suggests a unique role of FGF-8 in mouse development, especially in gastrulation, brain development, and limb and facial morphogenesis.
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