Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators

@article{Mukherjee1994HumanAR,
  title={Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators},
  author={R. Mukherjee and Lily Jow and D. Noonan and D. McDonnell},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1994},
  volume={51},
  pages={157-166}
}
We have isolated a human peroxisomal proliferator activated receptor (hPPAR) from a human liver cDNA library. Based on sequence analysis, we have determined that this cDNA encodes the human PPAR alpha. When assayed in a reconstituted hPPAR responsive transcription system in mammalian CV-1 cells, this receptor was shown to be transcriptionally activated by hypolipidemic agents like clofibric acid, and ETYA (5,8,11,14-eicosatetraynoic acid; a synthetic arachidonic acid homolog). When analyzed in… Expand
275 Citations
Peroxisome proliferator activated receptor-alpha expression in human liver.
Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes.
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References

SHOWING 1-10 OF 41 REFERENCES
Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.
Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.
Interaction of glucocorticoid analogues with the human glucocorticoid receptor
...
1
2
3
4
5
...