Human and rat liver UDP-glucuronosyltransferases are targets of ketoprofen acylglucuronide.

Abstract

Acylglucuronides formed from carboxylic acids by UDP-glucuronosyltransferases (UGTs) are electrophilic metabolites able to covalently bind proteins. In this study, we demonstrate the reactivity of the acylglucuronide from the nonsteroidal anti-inflammatory drug, ketoprofen, toward human and rat liver UGTs. Ketoprofen acylglucuronide irreversibly inhibited… (More)

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@article{Terrier1999HumanAR, title={Human and rat liver UDP-glucuronosyltransferases are targets of ketoprofen acylglucuronide.}, author={Nad{\`e}ge Terrier and Etienne Beno{\^i}t and Claire Senay and Françoise Lapicque and Anna Radomińska-Pandya and Jacques Magdalou and Sylvie Fournel-Gigleux}, journal={Molecular pharmacology}, year={1999}, volume={56 1}, pages={226-34} }