Human and mouse plasmacytoid dendritic cells.

  title={Human and mouse plasmacytoid dendritic cells.},
  author={Hubertus Hochrein and Meredith O'Keeffe and Hermann Wagner},
  journal={Human immunology},
  volume={63 12},
By virtue of their enormous potential to produce type I interferons it is clear that plasmacytoid dendritic cells are major players in the host defense against viruses and various pathogens. Plasmacytoid dendritic cells were first identified in humans and very recently the mouse equivalents have been isolated. This review focuses, where possible, on a comparison between the cells in these two species. The mouse and human plasmacytoid DC are remarkably similar in surface phenotype and they… CONTINUE READING

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