Human and methodological sources of variability in the measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine.

@article{Barregrd2013HumanAM,
  title={Human and methodological sources of variability in the measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine.},
  author={Lars Barreg{\aa}rd and Peter M\oller and Trine N{\ae}ss Henriksen and Vilas Mistry and Gudrun Koppen and Pavel Rossner and Radim J. {\vS}r{\'a}m and Allan Weimann and Henrik Enghusen Poulsen and Robert Nataf and Roberta Andreoli and Paola Manini and Tim Marczylo and Patricia Lam and M. D. R. Evans and Hiroshi Kasai and Kazuaki Kawai and Yun-shan Li and Kazuo Sakai and Rajinder Singh and Friederike Teichert and Peter B. Farmer and Rafal Rozalski and Daniel Gackowski and Agnieszka B. Siomek and Guillermo T S{\'a}ez and Concha Cerd{\'a} and Karin Broberg and Christian Lindh and Mohammad Bakhtiar Hossain and Siamak Haghdoost and Chiung-Wen Hu and M Z Chao and Kuen-Yuh Wu and Hilmi Orhan and Nilufer Senduran and Raymond J. Smith and Regina M. Santella and Yali Su and Czarina Cortez and Susan Yeh and Ryszard Olinski and Steffen Loft and Marcus S Cooke},
  journal={Antioxidants & redox signaling},
  year={2013},
  volume={18 18},
  pages={2377-91}
}
AIMS Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is a widely used biomarker of oxidative stress. However, variability between chromatographic and ELISA methods hampers interpretation of data, and this variability may increase should urine composition differ between individuals, leading to assay interference. Furthermore, optimal urine sampling conditions are not well defined. We performed inter-laboratory comparisons of 8-oxodG measurement between mass spectrometric-, electrochemical… CONTINUE READING
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