Human and canine gene homologs of porcine brain natriuretic peptide.

  title={Human and canine gene homologs of porcine brain natriuretic peptide.},
  author={J. J. Seilhamer and Ann Elizabeth Arfsten and Judith A. Miller and Patrik Lundquist and Robert Murry Scarborough and John A. Lewicki and John W. Porter},
  journal={Biochemical and biophysical research communications},
  volume={165 2},
A cDNA clone encoding porcine brain natriuretic peptide (BNP) precursor was used to probe a canine genomic DNA library for homologous sequences. A unique clone was obtained (D1) which encoded a peptide homologous to porcine BNP. A 4.0 kB Hind III fragment of D1 containing the entire BNP precursor coding region was hybridized against blots of EcoRI digested human genomic DNA. A 7.0 kB hybridizing band was observed, which was subsequently subcloned and sequenced. This human clone, H1, also… CONTINUE READING
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