Human and animal study on elimination from plasma and metabolism of diazepam after chronic alcohol intake.

@article{Sellman1975HumanAA,
  title={Human and animal study on elimination from plasma and metabolism of diazepam after chronic alcohol intake.},
  author={R. Sellman and Jussi H. Kanto and E Raijola and Aimo Pekkarinen},
  journal={Acta pharmacologica et toxicologica},
  year={1975},
  volume={36 1},
  pages={
          33-8
        }
}
: Very significantly lower concentrations of diazepam at 15 minutes and 1 hour after 10 mg intravenous diazepam injection were found in chronic alcoholic patients in comparison to healthy controls. Compared to 13 healthy controls a more rapid elimination of diazepam from the plasma of 14 chronic alcoholic patients during their alcohol-free period was observed. The alcoholics had a smaller concentration of the diazepam main metabolite, N-demethyl-diazepam, and at 3 hours this difference was… Expand
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