Human analogue of the morris water maze for testing subjects at risk of Alzheimer's disease.

@article{Lacz2010HumanAO,
  title={Human analogue of the morris water maze for testing subjects at risk of Alzheimer's disease.},
  author={Jan Lacz{\'o} and Ross Andel and Martin Vyhn{\'a}lek and Kamil Vl{\vc}ek and Hana Magerov{\'a} and Alexandra Varjassyov{\'a} and Martin Tolar and Jakub Hort},
  journal={Neuro-degenerative diseases},
  year={2010},
  volume={7 1-3},
  pages={148-52}
}
BACKGROUND Patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) have difficulties with spatial orientation. OBJECTIVE To test hypothesis that spatial navigation is impaired early in MCI patients representing the presymptomatic stage of AD. METHODS We tested patients with probable AD (n = 21), MCI, further classified according to Petersen's criteria as amnestic MCI (aMCI) single domain (n = 11), aMCI multiple domain (n = 31), or nonamnestic MCI (n = 7). The… CONTINUE READING
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