Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration.

@article{Craft2006HumanAB,
  title={Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration.},
  author={Jeffrey Craft and D Martin Watterson and Linda J. Van Eldik},
  journal={Glia},
  year={2006},
  volume={53 5},
  pages={484-90}
}
Using a human amyloid beta (Abeta) intracerebroventricular infusion mouse model of Alzheimer's disease-related injury, we previously demonstrated that systemic administration of a glial activation inhibitor could suppress neuroinflammation, prevent synaptic damage, and attenuate hippocampal-dependent behavioral deficits. We report that Abeta-induced neuroinflammation is an early event associated with onset and progression of pathophysiology, can be suppressed by the glial inhibitor over a range… CONTINUE READING
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