Human amyloid-beta causes changes in the levels of endothelial protein kinase C and its alpha isoform in vitro.

@article{Pkski2002HumanAC,
  title={Human amyloid-beta causes changes in the levels of endothelial protein kinase C and its alpha isoform in vitro.},
  author={Magdolna P{\'a}k{\'a}ski and Lajos Bal{\'a}spiri and Fr{\'e}d{\'e}ric Checler and P{\'e}ter K{\'a}sa},
  journal={Neurochemistry international},
  year={2002},
  volume={41 6},
  pages={
          409-14
        }
}
Amyloid-beta (A(beta)) deposits and neurofibrillary pathology are characteristic features of Alzheimer's disease (AD). The association of A(beta) with cerebral vessels is an intriguing feature of AD. While there is considerable evidence of altered activities of the major isoforms of protein kinase C (PKC) in the vasculature and neurons of AD brains, little is known about the relationship between the Abeta toxicity and the altered PKC levels in cerebral endothelial cells. In this study, cultured… CONTINUE READING