Human amnion epithelial cells mediate lung repair by directly modulating macrophage recruitment and polarization.

@article{Tan2014HumanAE,
  title={Human amnion epithelial cells mediate lung repair by directly modulating macrophage recruitment and polarization.},
  author={Jean Lee Tan and Siow Teng Chan and Euan M Wallace and Rebecca Lim},
  journal={Cell transplantation},
  year={2014},
  volume={23 3},
  pages={319-28}
}
Human amnion epithelial cells (hAECs) have been shown to modulate inflammation and restore normal lung structure and respiratory function following bleomycin challenge in immune-competent mice. These effects are exerted despite a lack of significant engraftment of hAECs, suggesting that immunomodulatory effect mechanisms are at play. In this study, using the bleomycin model of injury, we explored the interactions between hAECs and macrophages. We administered 4 million hAECs intraperitoneally… CONTINUE READING
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