Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity.

@article{Monick1999HumanAM,
  title={Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity.},
  author={Martha M. Monick and Aaron Brent Carter and Gary W. Hunninghake},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 25},
  pages={18075-80}
}
Although many functions of human alveolar macrophages are altered compared with their precursor cell, the blood monocyte (monocyte), the reason(s) for these functional changes have not been determined. We recently reported that human alveolar macrophages do not express AP-1 DNA binding activity (Monick, M. M., Carter, A. B., Gudmundsson, G., Geist, L. J., and Hunninghake, G. W. (1998) Am. J. Physiol. 275, L389-L397). To determine why alveolar macrophages do not express AP-1 DNA binding activity… CONTINUE READING

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