Human alveolar epithelial cells type II are capable of regulating T-cell activity.

@article{Zissel2000HumanAE,
  title={Human alveolar epithelial cells type II are capable of regulating T-cell activity.},
  author={Gernot Zissel and M. D. Ernst and Klaus Friedrich Rabe and Thomas I Papadopoulos and H. Magnussen and Max Schlaak and Joachim Mueller-Quernheim},
  journal={Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
  year={2000},
  volume={48 1},
  pages={66-75}
}
Alveolar epithelial cells type II (AEC-II) express MHC class II on their surface, an important prerequisite for antigen presentation. However, accessory signals are required for an efficient T-cell activation. We therefore isolated AEC-II from tumor-free sections of human lungs obtained by lobectomy/pneumectomy and purified the cells by magnetic-activated cell sorting. Furthermore, we tested the expression of CD54, CD58, CD80, and CD86 on AEC-II and evaluated their accessory function (AF) in… CONTINUE READING
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