Human alpha2-macroglobulin: genotype-phenotype relation.

  title={Human alpha2-macroglobulin: genotype-phenotype relation.},
  author={Gerd Birkenmeier and Ralf Mueller and Klaus Huse and Jochen Forberg and Christiane Glaeser and H C Hedrich and Sabine Nicklisch and Alex Reichenbach},
  journal={Experimental neurology},
  volume={184 1},
A pentanucleotide deletion polymorphism in the gene of alpha2-macrolgobulin (alpha2-M) is suggested to be associated with late-onset Alzheimer's disease (AD), though controversial results have been reported. The underlying assumption is that the intronic pentanucleotide deletion may affect the biological function and quantity of the inhibitor and thus contribute to the AD pathology. In the present study we have analyzed the distribution of the deletion polymorphism within a group of 227 healthy… CONTINUE READING