Human alpha-defensins block papillomavirus infection.

  title={Human alpha-defensins block papillomavirus infection.},
  author={Christopher B Buck and Patricia M. Day and Cynthia D. Thompson and Jacek T Lubkowski and Wuyuan Lu and Douglas R Lowy and John T. Schiller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 5},
Sexually transmitted human papillomaviruses (HPVs) are the primary cause of cervical cancer. Recent advances in techniques for production of papillomaviral vectors [known as pseudoviruses (PsVs)] have made it possible to perform high-throughput screens for compounds that might block the initial stages of papillomavirus infection. We have used PsVs to screen a variety of compounds that might function as inhibitors of HPV infection, with emphasis on human peptides previously implicated in innate… CONTINUE READING
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