Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism.

@article{Crosas2003HumanAR,
  title={Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism.},
  author={Bernat Crosas and David J Hyndman and Oriol Gallego and S{\'i}lvia Martras and Xavier Par{\'e}s and T. Geoffrey Flynn and Jaume Farr{\'e}s},
  journal={The Biochemical journal},
  year={2003},
  volume={373 Pt 3},
  pages={973-9}
}
Aldo-keto reductases (AKRs) are NAD(P)H-dependent oxidoreductases that catalyse the reduction of a variety of carbonyl compounds, such as carbohydrates, aliphatic and aromatic aldehydes and steroids. We have studied the retinal reductase activity of human aldose reductase (AR), human small-intestine (HSI) AR and pig aldehyde reductase. Human AR and HSI AR were very efficient in the reduction of all- trans -, 9- cis - and 13- cis -retinal ( k (cat)/ K (m)=1100-10300 mM(-1).min(-1)), constituting… CONTINUE READING
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