Human airway smooth muscle expresses 7 isoforms of adenylyl cyclase: a dominant role for isoform V.

@article{Xu2001HumanAS,
  title={Human airway smooth muscle expresses 7 isoforms of adenylyl cyclase: a dominant role for isoform V.},
  author={Dongrong Xu and Cary Isaacs and Ian P Hall and Charles W. Emala},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={281 4},
  pages={L832-43}
}
Adenylyl cyclases are a nine-member family of differentially regulated enzymes responsible for the synthesis of cAMP. cAMP is an important second messenger that contributes to the regulation of airway smooth muscle tone. However, little is known regarding the expression and regulation of adenylyl cyclase isoforms in airway smooth muscle cells. Nondegenerate specific primers were designed for all nine known isoforms of human adenylyl cyclase. RT-PCR experiments were performed using total RNA… CONTINUE READING

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