Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis.

@article{GnzalezRey2009HumanAS,
  title={Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis.},
  author={Elena G{\'o}nzalez-Rey and Per Anderson and Manuel Arellano Gonzalez and Laura Rico and Dirk B{\"u}scher and Mario Delgado},
  journal={Gut},
  year={2009},
  volume={58 7},
  pages={929-39}
}
BACKGROUND AND AIMS Inflammatory bowel diseases (IBDs) are associated with uncontrolled innate and adaptive immunity against normal constituents, including commensal bacteria and microbial products. Mesenchymal stem cells (MSCs) suppress effector T cell responses and have beneficial effects in various immune disorders. This work investigates the therapeutic effects of human adipose-derived MSCs (hASCs) in various models of IBD and sepsis. METHODS Acute and chronic colitis was induced in mice… CONTINUE READING
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