Human adipose tissue-derived mesenchymal stem cells protect kidneys from cisplatin nephrotoxicity in rats.

@article{Kim2012HumanAT,
  title={Human adipose tissue-derived mesenchymal stem cells protect kidneys from cisplatin nephrotoxicity in rats.},
  author={Jin H. Kim and Dong Jun Park and Ji Chul Yun and Myeong Hee Jung and Hee Dong Yeo and Hyun-Jung Kim and Dong Wook Kim and Jung Ill Yang and Gyeong-Won Lee and Sangho Jeong and Gu Seob Roh and Se-Ho Chang},
  journal={American journal of physiology. Renal physiology},
  year={2012},
  volume={302 9},
  pages={
          F1141-50
        }
}
Cisplatin has multiple cellular targets and modes of action that lead to nephrotoxicity. This suggests novel therapies that act at multiple cisplatin target sites may be effective. We tested whether human adipose tissue-derived mesenchymal stem cells (Ad-MSCs) can affect multiple target sites and protect against cisplatin-induced kidney damage. Rats were divided into four groups: control, infused with Ad-MSCs, injected with cisplatin, and cisplatin followed by infusion of Ad-MSCs. Animal… 
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Human adipose-derived mesenchymal stem cells repair cisplatin-induced acute kidney injury through antiapoptotic pathways.
TLDR
AD-MSCs were shown to markedly improve cisplatin-induced renal failure and tubular cells necrosis through the secretion of certain factors, which subsequently inhibited the apoptosis pathway in vitro.
Transplanted Adipose Derived Mesenchymal Stem Cells Attenuate The Acute Renal Injury Induced by Cisplatin in Rats
TLDR
Administration of adipose-derived mesenchymal stem cells (AD-MSCs) had a potential regenerative effect for the management of AKI and restored the renal histological architecture.
Study of the Effect of Route of Administration of Mesenchymal Stem Cells on Cisplatin-Induced Acute Kidney Injury in Sprague Dawley Rats
TLDR
MSCs by any routes were able to ameliorate kidney function deterioration and renal tissue damage induced by cisplatin, and differences between the different routes in one parameter were transient and inconsistent with other parameters.
The protective effect of human adiposederived mesenchymal stem cells on cisplatin-induced nephrotoxicity is dependent on their level of expression of heme oxygenase-1
TLDR
Renal tubular toxicity in cisplatin-treated rats was ameliorated by administration of hAd-MSCs with high HO-1 expression, although the levels of blood urea nitrogen and serum creatinine did not differ according to the level of HO- 1 expression.
Bone marrow-derived mesenchymal stem cells protect against cisplatin-induced acute kidney injury in rats by inhibiting cell apoptosis
TLDR
It is demonstrated that injecting rats with BM-MSCs protects renal function and structure in cisplatin-induced AKI by inhibiting cell apoptosis in vivo, and should be considered as a possible therapeutic strategy for the treatment of AKI.
Mesenchymal Stem Cells Attenuate Cisplatin-Induced Nephrotoxicity in iNOS-Dependent Manner
TLDR
MSCs, in iNOS-dependent manner, attenuated inflammation in cisplatin nephrotoxicity by reducing the influx and capacity of immune cells, particularly DCs and T lymphocytes, to produce inflammatory cytokines.
The Enhancement Effect of Mesenchymal Stem Cells on Nephrotoxicity Induced by Cisplatin in Albino Rats
TLDR
Administration of bone marrow derived mesenchymal stem cells improves nephrotoxicity as evidenced by the biochemical marker of inflammation (TNF a) and kidney function tests.
Mesenchymal stem cells versus their conditioned medium in the treatment of cisplatin-induced acute kidney injury : evaluation of efficacy and cellular side effects
TLDR
The results indicate that the use of CM might be an acceptable alternative to MSC therapy as it can attain comparable efficacy without the development of unwanted cells.
Long Term Study of Protective Mechanisms of Human Adipose Derived Mesenchymal Stem Cells on Cisplatin Induced Kidney injury in Sprague-Dawley Rats
TLDR
ADMSCs have both protective and regenerative abilities with consequent limitation of the development of renal fibrosis after the cisplatin induced acute tubular necrosis, largely through an anti-oxidative activity.
Role of Mesenchymal Stem Cells Versus their Conditioned Medium on Cisplatin-Induced Acute Kidney Injury in Albino Rat. A Histological and Immunohistochemical Study
TLDR
Treatment by BMSCs resulted in obvious improvement of renal structure with significant increase in Proliferating Cell Nuclear Antigen (PCNA), however, conditioned medium (CM) was less effective in treatment of acute AKI.
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