Human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase::uracil phosphoribosyltransferase inhibit intracerebral rat glioblastoma.

@article{Altanerova2012HumanAT,
  title={Human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase::uracil phosphoribosyltransferase inhibit intracerebral rat glioblastoma.},
  author={Veronika Altanerova and Marina Cihova and Michal Babi{\vc} and Boris Rychl{\'y} and Katar{\'i}na Ondi{\vc}ov{\'a} and Boris Mravec and Cestmir Altaner},
  journal={International journal of cancer},
  year={2012},
  volume={130 10},
  pages={2455-63}
}
Prodrug cancer gene therapy by mesenchymal stem cells (MSCs) targeted to tumors represents an attractive tool to activate prodrugs directly within the tumor mass, thus avoiding systemic toxicity. In this study, we tested the feasibility and efficacy of human adipose tissue-derived MSCs, engineered to express the suicide gene cytosine deaminase::uracil phosphoribosyltransferase to treat intracranial rat C6 glioblastoma. Experiments were designed to simulate conditions of future clinical… CONTINUE READING
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