Human adipose-derived mesenchymal stem cells systemically injected promote peripheral nerve regeneration in the mouse model of sciatic crush.

@article{Marconi2012HumanAM,
  title={Human adipose-derived mesenchymal stem cells systemically injected promote peripheral nerve regeneration in the mouse model of sciatic crush.},
  author={Silvia Marconi and Giusy Castiglione and Ermanna Turano and Guido Bissolotti and Stefano Angiari and Alessia Farinazzo and G. Constantin and Giorgio Bedogni and Alberto Bedogni and Bruno Bonetti},
  journal={Tissue engineering. Part A},
  year={2012},
  volume={18 11-12},
  pages={1264-72}
}
Mesenchymal stem cells (MSCs) represent a promising therapeutic approach in nerve tissue engineering. To date, the local implantation of MSC in injured nerves has been the only route of administration used. In case of multiple sites of injury, the systemic administration of cells capable of reaching damaged nerves would be advisable. In this regard, we found that an intravenous administration of adipose-derived MSC (ASC) 1 week after sciatic nerve crush injury, a murine model of acute axonal… CONTINUE READING
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