Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine.

@article{Frahm2012HumanAT,
  title={Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine.},
  author={Nicole Frahm and Allan C. deCamp and David P. Friedrich and Donald Carter and Olivier Damien Defawe and James G. Kublin and Danilo R. Casimiro and Ann C Duerr and Michael N. Robertson and Susan P Buchbinder and Yunda Huang and Gregory A. Spies and Stephen C. De Rosa and M Juliana McElrath},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 1},
  pages={359-67}
}
Recombinant viruses hold promise as vectors for vaccines to prevent infectious diseases with significant global health impacts. One of their major limitations is that preexisting anti-vector neutralizing antibodies can reduce T cell responses to the insert antigens; however, the impact of vector-specific cellular immunity on subsequent insert-specific T cell responses has not been assessed in humans. Here, we have identified and compared adenovirus-specific and HIV-specific T cell responses in… CONTINUE READING
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HIV-1 vaccineinduced immunity in the test-of-concept Step Study: a case-cohort analysis

  • M. J. McElrath, S. C. De Rosa, +7 authors R Akondy
  • 2008
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