Human acyl-CoA:diacylglycerol acyltransferase is a tetrameric protein.

@article{Cheng2001HumanAA,
  title={Human acyl-CoA:diacylglycerol acyltransferase is a tetrameric protein.},
  author={Dong Ping Cheng and Rupalie L Meegalla and Bingfang He and Debra A Cromley and Jeffrey T. Billheimer and Paul R. Young},
  journal={The Biochemical journal},
  year={2001},
  volume={359 Pt 3},
  pages={707-14}
}
Acyl-CoA:diacylglycerol acyltransferase (DGAT) is an integral membrane enzyme that catalyses the last step of triacylglycerol synthesis from diacylglycerol and acyl-CoA. Here we provide experimental evidence that DGAT is a homotetramer. Although the predicted molecular mass of human DGAT protein is 55 kDa, CHAPS-solubilized recombinant human DGAT was eluted in fractions over 150 kDa on gel-filtration chromatography. Cross-linking of recombinant DGAT in membranes with disuccinimidyl suberate… CONTINUE READING

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