Human acrocentric chromosomes with transcriptionally silent nucleolar organizer regions associate with nucleoli.

@article{Sullivan2001HumanAC,
  title={Human acrocentric chromosomes with transcriptionally silent nucleolar organizer regions associate with nucleoli.},
  author={G J Sullivan and Joanna M Bridger and Andrew P. Cuthbert and Robert F. Newbold and Wendy A. Bickmore and Brian McStay},
  journal={The EMBO journal},
  year={2001},
  volume={20 11},
  pages={
          2867-74
        }
}
Human ribosomal gene repeats are distributed among five nucleolar organizer regions (NORs) on the p arms of acrocentric chromosomes. On exit from mitosis, nucleoli form around individual active NORs. As cells progress through the cycle, these mini-nucleoli fuse to form large nucleoli incorporating multiple NORs. It is generally assumed that nucleolar incorporation of individual NORs is dependent on ribosomal gene transcription. To test this assumption, we determined the nuclear location of… CONTINUE READING

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