Human acid sphingomyelinase.

  title={Human acid sphingomyelinase.},
  author={Stephanie Lansmann and Christina G. Schuette and Oliver Bartelsen and J{\"o}rg H{\"o}rnschemeyer and Thomas Linke and Judith Weisgerber and Konrad Sandhoff},
  journal={European journal of biochemistry},
  volume={270 6},
Human acid sphingomyelinase (haSMase, EC catalyzes the lysosomal degradation of sphingomyelin to ceramide and phosphorylcholine. An inherited haSMase deficiency leads to Niemann-Pick disease, a severe sphingolipid storage disorder. The enzyme was purified and cloned over 10 years ago. Since then, only a few structural properties of haSMase have been elucidated. For understanding of its complex functions including its role in certain signaling and apoptosis events, complete structural… CONTINUE READING