Human acid beta-glucosidase: isolation and amino acid sequence of a peptide containing the catalytic site.

@article{Dinur1986HumanAB,
  title={Human acid beta-glucosidase: isolation and amino acid sequence of a peptide containing the catalytic site.},
  author={Tama Dinur and K M Osiecki and G{\"u}nther Legler and Shimon Gatt and Robert J Desnick and Gregory A. Grabowski},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 6},
  pages={1660-4}
}
Human acid beta-glucosidase (D-glucosyl-N-acylsphingosine glucohydrolase, EC 3.2.1.45) cleaves the glucosidic bonds of glucosylceramide and synthetic beta-glucosides. The deficient activity of this hydrolase is the enzymatic defect in the subtypes and variants of Gaucher disease, the most prevalent lysosomal storage disease. To isolate and characterize the catalytic site of the normal enzyme, brominated 3H-labeled conduritol B epoxide (3H-Br-CBE), which inhibits the enzyme by binding covalently… CONTINUE READING

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Human acid beta - glucosidase ( D - glucosyl - N - acylsphingosine glucohydrolase , EC 3.2.1.45 ) cleaves the glucosidic bonds of glucosylceramide and synthetic beta - glucosides .
Human acid beta - glucosidase ( D - glucosyl - N - acylsphingosine glucohydrolase , EC 3.2.1.45 ) cleaves the glucosidic bonds of glucosylceramide and synthetic beta - glucosides .
The deficient activity of this hydrolase is the enzymatic defect in the subtypes and variants of Gaucher disease , the most prevalent lysosomal storage disease .
Human acid beta - glucosidase ( D - glucosyl - N - acylsphingosine glucohydrolase , EC 3.2.1.45 ) cleaves the glucosidic bonds of glucosylceramide and synthetic beta - glucosides .
Human acid beta - glucosidase ( D - glucosyl - N - acylsphingosine glucohydrolase , EC 3.2.1.45 ) cleaves the glucosidic bonds of glucosylceramide and synthetic beta - glucosides .
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