Human Y Chromosome Base-Substitution Mutation Rate Measured by Direct Sequencing in a Deep-Rooting Pedigree

@inproceedings{Xue2009HumanYC,
  title={Human Y Chromosome Base-Substitution Mutation Rate Measured by Direct Sequencing in a Deep-Rooting Pedigree},
  author={Yali Xue and Qiuju Wang and Quan Long and Bee Ling Ng and Harold P Swerdlow and John A Burton and Carl D. Skuce and Ruth C. Taylor and Zahra Abdellah and Yali Zhao and Daniel G. MacArthur and Michael A. Quail and Nigel P. Carter and Huanming Yang and Chris Tyler-Smith},
  booktitle={Current Biology},
  year={2009}
}
Understanding the key process of human mutation is important for many aspects of medical genetics and human evolution. In the past, estimates of mutation rates have generally been inferred from phenotypic observations or comparisons of homologous sequences among closely related species. Here, we apply new sequencing technology to measure directly one… CONTINUE READING