Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms

@article{Wu2008HumanXC,
  title={Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms},
  author={Yili Wu and Taylor R. H. Mitchell and Xu-Dong Zhu},
  journal={Mechanisms of Ageing and Development},
  year={2008},
  volume={129},
  pages={602-610}
}
XPF-ERCC1, a structure-specific endonuclease, is involved in nucleotide excision repair, crosslink repair and homologous recombination. XPF-ERCC1 is also found to interact with TRF2, a duplex telomeric DNA binding protein. We have previously shown that XPF-ERCC1 is required for TRF2-promoted telomere shortening. However, whether XPF-ERCC1 by itself has a role in telomere length maintenance has not been determined. Here we report that overexpression of XPF induces telomere shortening in XPF… CONTINUE READING

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