Human XIST yeast artificial chromosome transgenes show partial X inactivation center function in mouse embryonic stem cells.

@article{Heard1999HumanXY,
  title={Human XIST yeast artificial chromosome transgenes show partial X inactivation center function in mouse embryonic stem cells.},
  author={Edith Heard and Fabien Mongelard and Danielle Arnaud and Corinne Chureau and Claire Vourc'h and P. Avner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 12},
  pages={6841-6}
}
Initiation of X chromosome inactivation requires the presence, in cis, of the X inactivation center (XIC). The Xist gene, which lies within the XIC region in both human and mouse and has the unique property of being expressed only from the inactive X chromosome in female somatic cells, is known to be essential for X inactivation based on targeted deletions in the mouse. Although our understanding of the developmental regulation and function of the mouse Xist gene has progressed rapidly, less is… CONTINUE READING

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