Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines.

@article{Gomez2007HumanXB,
  title={Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines.},
  author={Bianca P Gomez and Rebecca B. Riggins and Ayesha N. Shajahan and Uwe Klimach and Aifen Wang and Anatasha C. Crawford and Yuelin Zhu and Alan Zwart and Mingyue Wang and Robert Clarke},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2007},
  volume={21 14},
  pages={4013-27}
}
Human X-box binding protein-1 (XBP1) is an alternatively spliced transcription factor that participates in the unfolded protein response (UPR), a stress-signaling pathway that allows cells to survive the accumulation of unfolded proteins in the endoplasmic reticulum lumen. We have previously demonstrated that XBP1 expression is increased in antiestrogen-resistant breast cancer cell lines and is coexpressed with estrogen receptor alpha (ER) in breast tumors. The purpose of this study is to… CONTINUE READING
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