Human Vascular Wall Mesenchymal Stromal Cells Contribute to Abdominal Aortic Aneurysm Pathogenesis Through an Impaired Immunomodulatory Activity and Increased Levels of Matrix Metalloproteinase-9.

@article{Ciavarella2015HumanVW,
  title={Human Vascular Wall Mesenchymal Stromal Cells Contribute to Abdominal Aortic Aneurysm Pathogenesis Through an Impaired Immunomodulatory Activity and Increased Levels of Matrix Metalloproteinase-9.},
  author={Carmen Ciavarella and Francesco Alviano and Enrico Gallitto and Francesca Ricci and Marina Buzzi and Claudio V Velati and Andrea Stella and Antonio Freyrie and Gianandrea Pasquinelli},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  year={2015},
  volume={79 7},
  pages={1460-9}
}
BACKGROUND The main histopathological features of abdominal aortic aneurysm (AAA) are tissue proteolysis mediated by matrix metalloproteinases (MMPs) and inflammation. This study aimed at verifying the presence and contribution of mesenchymal stromal cells (MSCs) to aneurysmal tissue remodeling. METHODS AND RESULTS MSCs were successfully isolated from the AAA wall of 12 male patients and were found to express mesenchymal and stemness markers. MMP-2/-9 are involved in AAA progression and their… CONTINUE READING
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