Human Urotensin II Is a Novel Activator of NADPH Oxidase in Human Pulmonary Artery Smooth Muscle Cells

@article{Djordjevic2005HumanUI,
  title={Human Urotensin II Is a Novel Activator of NADPH Oxidase in Human Pulmonary Artery Smooth Muscle Cells},
  author={T. Djordjevic and R. S. Belaiba and Steve Bonello and J. Pfeilschifter and J. Hess and A. G{\"o}rlach},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology},
  year={2005},
  volume={25},
  pages={519-525}
}
  • T. Djordjevic, R. S. Belaiba, +3 authors A. Görlach
  • Published 2005
  • Biology, Medicine
  • Arteriosclerosis, Thrombosis, and Vascular Biology
  • Background—Human urotensin II (hU-II) is a potent vasoactive peptide possibly involved in pulmonary hypertension. Because the signaling mechanisms activated by this peptide in the pulmonary vasculature are largely unknown, we investigated the role of hU-II in the activation of NADPH oxidase and the control of redox-sensitive kinase pathways, expression of plasminogen activator inhibitor-1 (PAI-1), and proliferation in pulmonary artery smooth muscle cells (PASMCs). Methods and Results—hU-II… CONTINUE READING

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