Human ULK1 Variation and Susceptibility to Mycobacterium tuberculosis Infection.

  title={Human ULK1 Variation and Susceptibility to Mycobacterium tuberculosis Infection.},
  author={David J. Horne and Andrew D Graustein and Javeed A Shah and Glenna J. Peterson and Meg Savlov and Sergio Steele and Masahiro Narita and Thomas Richard Hawn},
  journal={The Journal of infectious diseases},
  volume={214 8},
BACKGROUND Unlike tuberculosis, few studies have evaluated a host genetic basis for variability in susceptibility to latent Mycobacterium tuberculosis infection (LTBI). We performed a candidate gene association study of autophagy-related genes and LTBI. METHODS We enrolled close contacts of individuals with pulmonary tuberculosis, assessed LTBI status, and determined clinical and sociodemographic risk factors for LTBI. In participants who self-identified as Asian or black, we compared… CONTINUE READING
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