Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium.

@article{Segawa2016HumanTI,
  title={Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium.},
  author={Katsumori Segawa and Sachiko Kurata and Shigekazu Nagata},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 2},
  pages={762-72}
}
In plasma membranes, flippases translocate aminophospholipids such as phosphatidylserine and phosphatidylethanolamine from the extracellular to the cytoplasmic leaflet. Mammalian ATP11C, a type IV P-type ATPase, acts as a flippase at the plasma membrane. Here, by expressing 12 human type IV P-type ATPases in ATP11C-deficient cells, we determined that ATP8A2… CONTINUE READING

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