Human Trophoblast Neoplasms

  title={Human Trophoblast Neoplasms},
  author={Roland A. Pattillo and Robert O. Hussa},
  journal={Advances in experimental medicine and biology},
  • R. Pattillo, R. Hussa
  • Published 1984
  • Biology, Medicine
  • Advances in experimental medicine and biology
S FIRST WORLD CONGRESS ON TROPHOBLAST NEOPLASMS October 25-27. 1982 University of Nairobi Medical School CONTENTS Nairobi. Kenya •• • • . • • • • 435 CONTRIBUTORS . . • • • • • • . • • • . • • • . • • . • • . • 465 INDEX. . . . . . . . • . . . . . . . . . . . . . . . . . . 471 PREGNANCY AND NEOPLASIA According to the available literature, the apparent difference in incidence in trophoblast neoplasms in the developing world, compared to the developed world, is an order of magnitude, ranging from… 

Gestational trophoblastic tumors in Norway, 1968-1997: patient characteristics, treatment, and prognosis.

It is shown that the prognosis of patients with GTT improved in the 1980s and 1990s in Norway, and that the FIGO system might be the best predictor of disease-free survival.

Exposure to chemical carcinogens during pregnancy: consequences for mother and conceptus.

  • J. Rice
  • Medicine
    Advances in experimental medicine and biology
  • 1984
The overwhelming majority of substances known to cause cancer when applied experimentally to animals and to have caused cancer in humans either as a result of industrial exposure or as a consequence of anti-tumor chemotherapy are organic compounds of low molecular weight, and it is exclusively with the latter that this overview will be concerned.

Laboratory Methods for the Quantitation of Human Chorionic Gonadotropin

This review discusses hCG monitoring from the laboratory perspective, with primary emphasis on the “beta-subunit radioimmunoassay,” the method that has become the standard by which other assay systems are currently judged.

Quantitation of human choriocarcinoma spheroid attachment to uterine epithelial cell monolayers.

An in vitro model system for the study of adhesion of human JAR choriocarcinoma multicellular spheroids to different human endometrial epithelial cell lines grown as monolayers is described and forms the basis for further studies on the molecular interactions involved.

Expression of Human Placental Hormone Genes in Growing and Growth-Inhibited (Transitional) Trophoblasts

Treatment of JEG-3 cells with the chemotherapeutic drug methotrexate (MTX) results in a trophoblast that has structural and biochemical characteristics intermediate between a cytotrophoblast and syncytiotrophoblow, and no effect on endogenous chorionic somatomammotropin RNA levels was detected.

Choriocarcinoma Cell Spheroids: An In Vitro Model for the Human Trophoblast

Among in vitro models proposed for studies of invasion, multicellular three-dimensional systems have been found to give more reliable data than two-dimensional (monolayer) systems.

Genetic Concepts and Techniques

The understanding of the separate molar syndromes has been much advanced by the application of genetic techniques of chromosome banding. These techniques allow not only for the identification of each



ABO blood-groups in trophoblastic neoplasia.

The data indicate that genetic factors strongly affect the development of choriocarcinoma, and these effects are possibly mediated immunologically, but the observations do not appear to conform with current concepts of tumour/host and materno/fetal interaction.

Trophoblastic neoplasia in an African urban population.

  • A. Agboola
  • Medicine
    Journal of the National Medical Association
  • 1979
The anterior vaginal wall is a common site for metastases of malignant trophoblastic neoplasia and, in one patient, the lesion progressed further to form a vesicovaginal fistula.

Gonadotropin therapy failure secondary to human chorionic gonadotropin-induced antibodies.

A 15-yr-old male with the diagnosis of Kallmann's syndrome manifested secondary gonadal resistance during a third treatment course of hCG, and data indicated that antibodies produced against hCG may bind other endogenous glycoproteins such as hLH, hFSH, and hTSH.

Widespread distribution of a chorionic gonadotropin-like substance in normal human tissues.

It is indicated that an hCG-like substance is widely distributed throughout normal human tissues and further supports the concept that the fetal genome responsible for hCG production is not completely suppressed in adult tissues.

The biochemical properties of urinary human chorionic gonadotropin from the patients with trophoblastic diseases

The present findings support the thesis that neoplastic or malignant transformation of trophoblasts may result in an alteration of the glycosylation process, especially the sialylation, in the biosynthesis of hCG rather than the translation steps.

Gynaecologic and Obstetric Pathology (With Clinical and Endocrine Relations)

  • H. Fox
  • Medicine
    British Journal of Cancer
  • 1980
This is an excellent review of recent literature on proteins and glycoproteins cf animal cell membranes. The author is one of the foremost authorities in membrane research, and he seems fully at ease

Isoimmunization against human chorionic gonadotropin with conjugates of processed beta-subunit of the hormone and tetanus toxoid.

The immunogenicity of the conjugate prepared from "processed" beta-subunit of human chorionic gonadotropin (choriogonadotropin, HCG) and tetanus toxoid has been studied in animals and a human

Antibodies to human chorionic gonadotropin in humans.

A simple and sensitive color test for the detection of human chorionic gonadotropin.

A simple, rapid, sensitive, and reliable ELISA test for the detection of urinary human chorionic gonadotropin (hCG) has been developed using penicillinase (EC no. as the label and a