Human Transposon Tectonics

@article{Burns2012HumanTT,
  title={Human Transposon Tectonics},
  author={Kathleen H. Burns and Jef D. Boeke},
  journal={Cell},
  year={2012},
  volume={149},
  pages={740-752}
}
Mobile DNAs have had a central role in shaping our genome. More than half of our DNA is comprised of interspersed repeats resulting from replicative copy and paste events of retrotransposons. Although most are fixed, incapable of templating new copies, there are important exceptions to retrotransposon quiescence. De novo insertions cause genetic diseases and cancers, though reliably detecting these occurrences has been difficult. New technologies aimed at uncovering polymorphic insertions… CONTINUE READING
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