Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

@inproceedings{Haniffa2012HumanTC,
  title={Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells},
  author={Muzlifah Haniffa and Amanda Shin and Venetia Bigley and Naomi McGovern and Pearline Zhaoying Teo and Peter See and Pavandip Singh Wasan and Xiao-Nong Wang and Frano Malinarich and Benoit Malleret and Anis Larbi and Pearlie W. W. Tan and Helen Zhao and Michael Poidinger and Sarah Pagan and Sharon Cookson and Rachel Emma Dickinson and Ian Dimmick and Ruth F. Jarrett and Laurent R{\'e}nia and John Kit Chung Tam and Colin Song and John Edward Connolly and Jerry K.Y. Chan and Adam J. Gehring and Antonio Bertoletti and Matthew Collin and Florent Ginhoux},
  booktitle={Immunity},
  year={2012}
}
Dendritic cell (DC)-mediated cross-presentation of exogenous antigens acquired in the periphery is critical for the initiation of CD8(+) T cell responses. Several DC subsets are described in human tissues but migratory cross-presenting DCs have not been isolated, despite their potential importance in immunity to pathogens, vaccines, and tumors and tolerance to self. Here, we identified a CD141(hi) DC present in human interstitial dermis, liver, and lung that was distinct from the majority of… CONTINUE READING
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