Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26).

@article{Bengsch2012HumanTC,
  title={Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26).},
  author={Bertram Bengsch and Bianca Seigel and Tobias Flecken and Julia Wolanski and H. E. Blum and Robert Thimme},
  journal={Journal of immunology},
  year={2012},
  volume={188 11},
  pages={5438-47}
}
Dipeptidylpeptidase IV (CD26) is a multifunctional ectoenzyme involved in T cell activation that has been implicated in autoimmune pathophysiology. Because IL-17-producing CD4(+) T cells (Th17 cells) are important mediators of autoimmune disease, we analyzed the expression of CD26 and its enzymatic function on human Th17 cells. Analysis of CD26 expression on different CD4(+) T helper subsets showed that CD26 expression is highest on CD4(+) T cells producing type 17 cytokines (e.g., IL-22, IL-17… CONTINUE READING
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