Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair

@inproceedings{Rochette2010HumanTA,
  title={Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair},
  author={Patrick J Rochette and Douglas E. Brash},
  booktitle={PLoS genetics},
  year={2010}
}
Telomeric repeats preserve genome integrity by stabilizing chromosomes, a function that appears to be important for both cancer and aging. In view of this critical role in genomic integrity, the telomere's own integrity should be of paramount importance to the cell. Ultraviolet light (UV), the preeminent risk factor in skin cancer development, induces mainly cyclobutane pyrimidine dimers (CPD) which are both mutagenic and lethal. The human telomeric repeat unit (5'TTAGGG/CCCTAA3') is nearly… CONTINUE READING

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