Human Tear Fluid Reduces Culturability of Contact Lens-Associated Pseudomonas aeruginosa Biofilms but Induces Expression of the Virulence-Associated Type III Secretion System.

@article{Wu2017HumanTF,
  title={Human Tear Fluid Reduces Culturability of Contact Lens-Associated Pseudomonas aeruginosa Biofilms but Induces Expression of the Virulence-Associated Type III Secretion System.},
  author={Yvonne Tzu-Ying Wu and Connie Tam and Lucia S Zhu and David W Evans and Suzanne M. J. Fleiszig},
  journal={The ocular surface},
  year={2017},
  volume={15 1},
  pages={
          88-96
        }
}
PURPOSE The type III secretion system (T3SS) is a significant virulence determinant for Pseudomonas aeruginosa. Using a rodent model, we found that contact lens (CL)-related corneal infections were associated with lens surface biofilms. Here, we studied the impact of human tear fluid on CL-associated biofilm growth and T3SS expression. METHODS P. aeruginosa biofilms were formed on contact lenses for up to 7 days with or without human tear fluid, then exposed to tear fluid for 5 or 24 h… CONTINUE READING

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